منابع مشابه
Non-coding RNAs: could they be the answer?
Despite a considerable amount of effort by different groups to evaluate the genetic traits associated with complex diseases by genome-wide association studies (GWAS), just a few regions, mainly linked to protein-coding genes, were identified. Recently, studies from different groups have implicated new classes of long non-coding RNAs (ncRNAs) to important molecular mechanisms. Additionally, high...
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Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...
متن کاملLong non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
متن کاملthe role of long non-coding rnas in ovarian cancer
background: ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. however, the aim of this review was to investigate the role of long n...
متن کاملThe Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2010
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elq029